Synthesis and biological evaluation of novel 2, 6-diaminobenz [cd] indole inhibitors of thymidylate synthase using the protein structure as a guide

MD Varney, CL Palmer, JG Deal…

Index: Journal of Medicinal Chemistry, , vol. 38, # 11 p. 1892 - 1903

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Citation Number: 32

Abstract

... The result is that the benzindole is not as well accommodated by the E. coli enzyme and therefore binds 0 1995 American Chemical Society Page 2. Synthesis of 2,6-Diaminobenz[cd]indole Inhibitors of TS Journal of Medicinal Chemistry, 1995, Vol. 38, No. 11 1893 ...