in vitro inhibition of the measles virus by novel ring-expanded ('fat') nucleoside analogues containing the imidazo [4, 5-e][1, 3] diazepine ring system

…, K Kalicharran, AI Fattom, RB Naso, DL Barnard…

Index: Zhang, Ning; Chen, Huan-Ming; Sood, Ramesh; Kalicharran, Kishna; Fattom, Ali I; Naso, Robert B; Barnard, Dale L; Sidwell, Robert W; Hosmane, Ramachandra S Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 23 p. 3391 - 3394

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Citation Number: 11

Abstract

The synthesis and in vitro anti-measles virus (anti-MV) activity of a class of ring-expanded ('fat') nucleoside analogues (1–4) containing the title heterocyclic ring system are reported. The target compounds were synthesized by base-catalyzed condensations of 4, 5- dicarboxylic acid esters of the appropriately substituted imidazole-1-ribosides with suitably substituted guanidine derivatives. Compounds were screened for anti-MV activity in ...