Activity of 7-methyljuglone derivatives against Mycobacterium tuberculosis and as subversive substrates for mycothiol disulfide reductase

…, JJM Meyer, F Van der Kooy, P Houghton, N Lall

Index: Mahapatra, Anita; Mativandlela, Sannah P.N.; Binneman; Fourie; Hamilton, Chris J.; Meyer; van der Kooy; Houghton, Peter; Lall, Namrita Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 24 p. 7638 - 7646

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Citation Number: 61

Abstract

The naphthoquinone 7-methyljuglone (5-hydroxy-7-methyl-1, 4-naphthoquinone) has previously been isolated and identified as an active component of root extracts of Euclea natalensis which displays antitubercular activity. Herein, a series of synthetic and plant- derived naphthoquinone derivates of the 7-methyljuglone scaffold have been prepared and evaluated for antibacterial activity against Mycobacterium tuberculosis. Several of these ...