Synthesis and antidepressant properties of novel 2-substituted 4, 5-dihydro-1H-imidazole derivatives

MP Wentland, DM Bailey, EJ Alexander…

Index: Wentland; Bailey; Alexander; Castaldi; Ferrari; Haubrich; Luttinger; Perrone Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1482 - 1489

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Citation Number: 13

Abstract

A unique combination of a2-adrenoreceptor antagonist and serotonin-selective reuptake inhibitory activities has been identified in a series of 2-substituted 4, 5-dihydro-lH-imidaole derivatives. This combination of blocking activities has provided one of these derivatives, napamezole hydrochloride (2), with potential as an antidepressant. A discussion of the syntheses of these compounds includes a convenient method for the conversion of nitriles ...