Lipophilic 4-imidazoly-1, 4-dihydropyridines: synthesis, calcium channel antagonist activity and protection against pentylenetetrazole-induced seizure
L Navidpour, H Shafaroodi, R Miri, AR Dehpour…
Index: Navidpour, Latifeh; Shafaroodi, Hamed; Miri, Ramin; Dehpour, Ahmad Reza; Shafiee, Abbas Farmaco, 2004 , vol. 59, # 4 p. 261 - 269
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Citation Number: 31
Abstract
A group of alkyl, cycloalkyl and aryl ester analogs of nifedipine, in which the o-nitrophenyl group at position 4 is replaced by a 2-phenyl-4 (5)-imidazolyl substituent, were synthesized and evaluated as calcium channel antagonist using the high K+ contraction of guinea-pig ileal longitudinal smooth muscle, and the activity of 5a–d, 8b and 8f against pentylenetetrazole (PTZ)-induced seizure was assessed. The results for symmetrical ...
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