Determination of optimal operation conditions for production of cephalosporin G from penicillin G potassium

…, R Yegani, R Hajmohammadi

Index: Salehpour, Pooneh; Yegani, Reza; Hajmohammadi, Reza Organic Process Research and Development, 2012 , vol. 16, # 9 p. 1507 - 1512

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Citation Number: 4

Abstract

Cephalosporin G (Ceph-G) is one of the most important components for producing β-lactam antibiotics. It is also a starting material for the synthesis of cephalosporin antibiotics. Ceph-G was produced from penicillin G potassium (Pen-GK) during multiple steps consisting of conversion of Pen-GK to penicillin G sulfoxide followed by dehydration and ring expansion to produce Ceph-G. In this work, the amount of all starting materials and stoichiometric ...