Design, synthesis and biological evaluation of Rose Bengal analogues as SecA inhibitors

…, J Jin, YH Hsieh, H Yang, B Ke, K Damera…

Index: Cui, Jianmei; Jin, Jinshan; Hsieh, Ying-Hsin; Yang, Hsiuchin; Ke, Bowen; Damera, Krishna; Tai, Phang C.; Wang, Binghe ChemMedChem, 2013 , vol. 8, # 8 p. 1384 - 1393

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Citation Number: 14

Abstract

Abstract SecA, a key component of bacterial Sec-dependent secretion pathway, is an attractive target for exploring novel antimicrobials. Rose bengal (RB), a polyhalogenated fluorescein derivative, was found from our previous study as a potent SecA inhibitor. Here we describe the synthesis and structure–activity relationships (SAR) of 23 RB analogues that were designed by systematical dissection of RB. Evaluation of these analogues ...