Nondepressant. beta.-adrenergic blocking agents. 1. Substituted 3-amino-1-(5, 6, 7, 8-tetrahydro-1-naphthoxy)-2-propanols

…, VL Narayanan, J Reid, JE Sundeen…

Index: Condon; Cimarusti; Fox; Narayanan; Reid; Sundeen; Hauck Journal of Medicinal Chemistry, 1978 , vol. 21, # 9 p. 913 - 922

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Citation Number: 15

Abstract

A series of 3-amino-1-(5, 6, 7, 8-tetrahydronaphthoxy)-2-propanols was synthesized and investigated for 6-adrenergic blocking activity and direct myocardial depressant action. The cis-and trans-diols 12-15 were found to retain the@-blocking potency of propranolol but to lack its myocardial depressant action. Compound 15 (nadolol) is currently undergoing extensive clinical evaluation as a potential antianginal, antiarrhythmic, and ...