A facile hydroxyindole carboxylic acid based focused library approach for potent and selective inhibitors of Mycobacterium protein tyrosine phosphatase B

…, Y He, R He, L Wu, AM Gunawan, ZY Zhang

Index: Zeng, Li-Fan; Xu, Jie; He, Yantao; He, Rongjun; Wu, Li; Gunawan, Andrea M.; Zhang, Zhong-Yin ChemMedChem, 2013 , vol. 8, # 6 p. 904 - 908

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Citation Number: 12

Abstract

Protein tyrosine phosphatases (PTPs) are key regulators of intracellular signaling pathways that control a broad range of physiological processes, including cell growth and differentiation, metabolism, apoptosis, and immune responses.[1] Not surprisingly, altered PTP activities result in aberrant tyrosine phosphorylation, which has been linked to the etiology of many human diseases, including cancer, diabetes, and immune dysfunctions.[ ...