Comparison of triple quadrupole, hybrid linear ion trap triple quadrupole, time??of??flight and LTQ??Orbitrap mass spectrometers in drug discovery phase metabolite …

…, J Herttuainen, A Tolonen

Index: Rousu, Timo; Herttuainen, Jukka; Tolonen, Ari Rapid Communications in Mass Spectrometry, 2010 , vol. 24, # 7 p. 939 - 957

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Citation Number: 64

Abstract

Abstract Liquid chromatography in combination with mass spectrometry (LC/MS) is a superior analytical technique for metabolite profiling and identification studies performed in drug discovery and development laboratories. In the early phase of drug discovery the analytical approach should be both time-and cost-effective, thus providing as much data as possible with only one visit to the laboratory, without the need for further experiments. ...