New analogues of butylated hydroxytoluene as anti-inflammatory and antioxidant agents

…, AM Gavalas, PT Eleftheriou, PN Kourounakis

Index: Ziakas, George N.; Rekka, Eleni A.; Gavalas, Antonios M.; Eleftheriou, Phaedra T.; Kourounakis, Panos N. Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 16 p. 5616 - 5624

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Citation Number: 35

Abstract

Amine or amide derivatives bearing the 2, 6-di-tert-butyl phenol moiety are synthesised. Almost all are antioxidants, reduce acute inflammation and inhibit COX-1 and lipoxygenase activity. The most potent anti-inflammatory, COX-1 inhibitor and antioxidant agent, with low toxicity, is 2, 6-di-tert-butyl-4-thiomorpholin-4-ylmethyl-phenol.