xenobiotica

In vitro biotransformation of 2, 6, 9-trisubstituted purine-derived cyclin-dependent kinase inhibitor bohemine by mouse liver microsomes

…, Z Chmela, D Riegrová, K Červenková, L Havlíček…

Index: Rypka; Vesely; Chmela; Riegrova; Cervenkova; Havliek; Lemr; Hanus; Cerny; Lukes; Michalikova Xenobiotica, 2002 , vol. 32, # 11 p. 1017 - 1031

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Citation Number: 7

Abstract

1. Biotransformation pathways of the cyclin-dependent kinase inhibitor 6-benzylamino-2-(3- hydroxypropylamino)-9-isopropylpurine (bohemine) by mouse liver microsomes in vitro were investigated. 2. Metabolite profiles of [8-3H]-labelled bohemine were established by TLC/3H-autoradiography and enzymatic and MS analyses were used to elucidate the chemical structures of the metabolites. The structures of the main primary metabolites ...