Overall synthesis of GSK356278: quick delivery of a PDE4 inhibitor using a fit-for-purpose approach
G Guercio, D Castoldi, N Giubellina…
Index: Organic Process Research and Development, , vol. 14, # 5 p. 1153 - 1161
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Abstract
... Organic Process Research & Development. ... In fact, this procedure allowed minimizing the degradation of the coupling agent due to the interaction with hydrazinecarboxylate. ... led to the isolation of intermediate 9, a new stage 5 was introduced in the process (see Scheme 4 ...
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Overall synthesis of GSK356278: quick delivery of a PDE4 inhibitor using a fit-for-purpose approach
[Guercio, Giuseppe; Castoldi, Damiano; Giubellina, Nicola; Lamonica, Alessandro; Ribecai, Arianna; Stabile, Paolo; Westerduin, Pieter; Dams, Riet; Nicoletti, Anna; Rossi, Sara; Bismara, Claudio; Provera, Stefano; Turco, Lucilla Organic Process Research and Development, 2010 , vol. 14, # 5 p. 1153 - 1161]