Synthetic communications

Efficient synthesis of a selective Y5 receptor antagonist

S Guery, Y Rival, CG Wermuth

Index: Guery, Sebastien; Rival, Yveline; Wermuth, Camille G. Synthetic Communications, 2002 , vol. 32, # 11 p. 1715 - 1719

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Abstract

View all references and we wanted to use it as a reference for the biologic testing of our own compounds. The description of the synthesis of the reference compound 8 in the Banyu patent is limited to the last step, a Wittig-Horner reaction between 6-methyl-4-pyrrolidinylpyridine-2- carboxaldehyde 7 and 3-trifluoromethylbenzyldiethylphosphonate. ... In this paper, we describe the complete synthetic sequence leading to compound 8 which may be useful to the ...