3′-Bromo analogues of pyrimidine nucleosides as a new class of potent inhibitors of Mycobacterium tuberculosis

…, B Agrawal, DY Kunimoto, R Kumar

Index: Rai, Dinesh; Johar, Monika; Srivastav, Naveen C.; Manning, Tracey; Agrawal; Kunimoto, Dennis Y.; Kumar, Rakesh Journal of Medicinal Chemistry, 2007 , vol. 50, # 19 p. 4766 - 4774

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Citation Number: 18

Abstract

Tuberculosis (TB) is a major health problem worldwide. We herein report a new class of pyrimidine nucleosides as potent inhibitors of Mycobacterium tuberculosis (M. tuberculosis). Various 2′-or 3′-halogeno derivatives of pyrimidine nucleosides containing uracil, 5- fluorouracil, and thymine bases were synthesized and evaluated for antimycobacterial activities. Among the compounds tested, 3′-bromo-3′-deoxy-arabinofuranosylthymine ( ...