Solution and Solid-State Models of Peptide CH⊙⊙⊙ O Hydrogen Bonds

…, BA Helfrich, W Pérez-Segarra, J Desper

Index: Baures, Paul W.; Beatty, Alicia M.; Dhanasekaran, Muthu; Helfrich, Brian A.; Perez-Segarra, Waleska; Desper, John Journal of the American Chemical Society, 2002 , vol. 124, # 38 p. 11315 - 11323

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Citation Number: 35

Abstract

Fumaramide derivatives were analyzed in solution by 1H NMR spectroscopy and in the solid state by X-ray crystallography in order to characterize the formation of CH⊙⊙⊙ O interactions under each condition and to thereby serve as models for these interactions in peptide and protein structure. Solutions of fumaramides at 10 mM in CDCl3 were titrated with DMSO-d 6, resulting in chemical shifts that moved downfield for the CH groups ...