A Facile Route for Synthesis of (?)-Dinoprost,(?)-Carboprost and Its Analogs
…, MH Krishna, PM Rao, T Lakshmikumar…
Index: Shankar; Mohan, H. Rama; Prasad, U. Viplava; Krishna, M. Hari; Rao, P. Mareswar; Lakshmikumar; Subbaraju, Gottumukkala V. Asian Journal of Chemistry, 2013 , vol. 25, # 2 p. 913 - 920
Full Text: HTML
Citation Number: 0
Abstract
Abstract A general synthetic approach was developed for (±)-dinoprost (1),(±)-carboprost (2) and their analogs (3-5) through a key intermediate (6). Compound 6 can be converted into the target compounds in two or three steps. Diastereomeric separation was accomplished easily for obtaining (±) dinoprost. Separation of diastereomers was difficult for (±) carboprost and their analogs. Key intermediate 6 was obtained, in turn, from (±)-corey lactone.
Related Articles:
A unique palladium catalyst for efficient and selective alkoxycarbonylation of olefins with formates
[Fleischer, Ivana; Jennerjahn, Reiko; Cozzula, Daniela; Jackstell, Ralf; Franke, Robert; Beller, Matthias ChemSusChem, 2013 , vol. 6, # 3 p. 417 - 420]
Polarity of the acid chain of esters and transesterification activity of acid catalysts
[Journal of Catalysis, , vol. 262, # 1 p. 18 - 26]
A highly efficient deoxygenation of α-oxygenated esters via SmI 2-induced electron transfer process
[Kusuda, Kazuhiro; Junji, Inanaga; Yamaguchi, Masaru Tetrahedron Letters, 1989 , vol. 30, # 22 p. 2945 - 2948]
[Hiegel, Gene A.; Gilley, Cynthia B. Synthetic Communications, 2003 , vol. 33, # 12 p. 2003 - 2009]
[Angewandte Chemie - International Edition, , vol. 47, # 3 p. 560 - 563]