Chemistry and structure of modified uridines in the anticodon, wobble position of transfer RNA are determined by thiolation

H Sierzputowska-Gracz, E Sochacka…

Index: Sierzputowska-Gracz; Sochacka; Malkiewicz; Kuo; Gehrke; Agris Journal of the American Chemical Society, 1987 , vol. 109, # 23 p. 7171 - 7177

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Citation Number: 97

Abstract

Abstract: Uridines found in the first or wobble position of transfer RNA anticodons are most often modified at base ring carbon-5 and many times also thiolated at carbon-2. It is important to understand the chemistry and structure of the modified uridines because they influence codon recognition by tRNA. Uridine and five biologically important 5-position derivatives and the six analogous 2-thiouridines were all investigated by high- ...