Tetrahedron letters

Aza-annulation as a versatile approach to the synthesis of non-benzodiazepene compounds for the treatment of sleep disorders

P Benovsky, JR Stille

Index: Benovsky, Petr; Stille, John R. Tetrahedron Letters, 1997 , vol. 38, # 49 p. 8475 - 8478

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Citation Number: 25

Abstract

The aza-annulation of enamino ester substrates has been demonstrated as an efficient alternative to the syntheses of non-benzodiazepine sleep inducers. Enamino ester substrates derived from aryl, thiophene, and indole functionality were prepared from the corresponding ethyl amines by isothiocyanate formation followed by acid catalyzed cyclization.