Macrocyclization of Di??Boc??guanidino??alkylamines Related to Guazatine Components: Discovery and Synthesis of Innovative Macrocyclic Amidinoureas
D Castagnolo, F Raffi, G Giorgi…
Index: Castagnolo, Daniele; Raffi, Francesco; Giorgi, Gianluca; Botta, Maurizio European Journal of Organic Chemistry, 2009 , # 3 p. 334 - 337
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Citation Number: 14
Abstract
Abstract The synthesis of new and innovative macrocyclic amidinoureas from linear di-Boc- guanidino-alkylamines related to guazatine was accomplished. The macrocyclization reaction proceeds under mild conditions affording 11-to 16-membered rings with a new and previously undescribed structure in good yields. Enantiomerically pure macrocyclic amidinoureas were also synthesised. The strict correlation between macrocyclic ...
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