Advanced Synthesis & Catalysis

First Copper??Catalyzed Intramolecular Amidation in Substituted 4??Iodopyrazoles Leading to the Synthesis of Pyrazolo [4, 3??b]??pyridin??5??ones

S Nag, M Nayak, S Batra

Index: Nag, Somnath; Nayak, Maloy; Batra, Sanjay Advanced Synthesis and Catalysis, 2009 , vol. 351, # 16 p. 2715 - 2723

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Citation Number: 16

Abstract

Abstract An unprecedented copper-catalyzed intramolecular amidation of substituted 4- iodopyrazoles generated either via Baylis–Hillman or Horner–Wadsworth–Emmons chemistry for the synthesis of pyrazolo [4, 3-b] pyridine-5-ones is described. In addition, the effect of the stereochemistry of the acrylamide on the cross-coupling reaction has been investigated and it is demonstrated that only the Z-isomer is favoured to undergo the ...