Synthesis and Biological Activity of the Metabolites of Diethyl 4-((4-Bromo-2-cyanophenyl) carbamoyl) benzylphosphonate (NO-1886).

…, S NAKAMURA, Y MORIOKA, M KONDO…

Index: Goto; Nakamura; Morioka; Kondo; Naito; Tsutsumi Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 3 p. 547 - 551

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Citation Number: 7

Abstract

Five metabolites of diethyl 4-[(4-bromo-2-cyanophenyl) carbamoyl] benzylphosphonate (NO- 1886)(1) were synthesized to confirm their proposed structures. The metabolites (2-6) were found to be identical with the synthesized compounds. These metabolites were orally administrated to Triton WR-1339-induced hypertriglyceridemic rats, and the plasma levels of triglycerides were measured to estimate lipoprotein lipase activity. All the metabolites ...