Simplified YM-26734 inhibitors of secreted phospholipase A 2 group IIA

RC Oslund, N Cermak, CLMJ Verlinde…

Index: Oslund, Rob C.; Cermak, Nathan; Verlinde, Christophe L.M.J.; Gelb, Michael H. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5415 - 5419

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Citation Number: 17

Abstract

Simplified analogs of YM-26734, a known inhibitor of secreted phospholipase A2 (sPLA2) group IIA, were synthesized and found to also display potent inhibition at low nanomolar concentrations. Analogs were based on the didodecanoylphloroglucinol portion of YM- 26734 which contains the predicted active site calcium binding group.