Discovery and synthesis of methyl 2, 5-dimethyl-4-[2-(phenylmethyl) benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogs: the first examples of a new class of …

…, J Dixon, F Ince, CN Manners, SJ Teague

Index: Baxter; Dixon; Ince; Manners; Teague Journal of Medicinal Chemistry, 1993 , vol. 36, # 19 p. 2739 - 2744

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Citation Number: 28

Abstract

Methyl 2, 5-dimethyl-4-[2-(phenylmethyl) benzoyll-1H-pyrrole-3-carboxylate, FPL 64176 (l), is the first example of a new class of calcium channel activator (CCA) that does not act on any of the well-defined calcium channel modulator receptor sites, as typified by verapamil, diltiazem, and the dihydropyridines. The potent activity of 1, having the 2-(phenylmethy1) benzoyl substituent, was predicted using QSAR on an initial set of less potent ...