Novel piperidinyloxy oxazolidinone antibacterial agents. Diversification of the N-substituent

MA Weidner-Wells, CM Boggs, BD Foleno…

Index: Weidner-Wells, Michele A.; Boggs, Christine M.; Foleno, Barbara D.; Melton, John; Bush, Karen; Goldschmidt, Raul M.; Hlasta, Dennis J. Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 7 p. 2345 - 2351

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Citation Number: 30

Abstract

Oxazolidinone antibacterial agents, where the morpholino group of linezolid was replaced with an N-substituted piperidinyloxy moiety, were synthesized and shown to be active against a variety of resistant and susceptible Gram-positive organisms. The functionality attached to the piperidine nitrogen was varied extensively to determine the SAR for this series. One of the most potent compounds, 11, showed in vivo efficacy upon ...