Noncovalent interactions between tetrazole and an N, N'-diethyl-substituted benzamidine

L Peters, R Fröhlich, ASF Boyd…

Index: Peters; Froehlich; Boyd; Kraft Journal of Organic Chemistry, 2001 , vol. 66, # 10 p. 3291 - 3298

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Citation Number: 41

Abstract

Amidines have long been known to form strong noncovalent complexes with carboxylates and phosphates. However, their interaction with tetrazoles, which are acidic heterocycles and important bioisosteric replacements for carboxylic acids in medicinal chemistry, has remained unexplored so far. The binding of a tetrazole to an N, N'-diethyl-substituted benzamidine has been studied for the first time by X-ray crystallography, solution NMR ...