Synthesis and biological evaluation of berberine analogues as novel up-regulators for both low-density-lipoprotein receptor and insulin receptor
YX Wang, YP Wang, H Zhang, WJ Kong, YH Li…
Index: Wang, Yan-Xiang; Wang, Yu-Ping; Zhang, Hao; Kong, Wei-Jia; Li, Ying-Hong; Liu, Fei; Gao, Rong-Mei; Liu, Ting; Jiang, Jian-Dong; Song, Dan-Qing Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 21 p. 6004 - 6008
Full Text: HTML
Citation Number: 47
Abstract
Berberine (BBR) is a natural compound with up-regulating activity on both low-density- lipoprotein receptor (LDLR) and insulin receptor (InsR). This one-drug-multiple-target characteristic might be suitable for the treatment of metabolic syndrome. In searching for up- regulators effective for both LDLR and InsR expression, the structure–activity relationship (SAR) analysis for BBR analogues was done. Fourteen BBR analogues were designed, ...
Related Articles:
[Anderson, Wayne K.; McPherson, Howard L.; New, James S.; Rick, Arvela C. Journal of Medicinal Chemistry, 1984 , vol. 27, # 10 p. 1321 - 1325]
[Anderson, Wayne K.; McPherson, Howard L.; New, James S.; Rick, Arvela C. Journal of Medicinal Chemistry, 1984 , vol. 27, # 10 p. 1321 - 1325]
Macrocyclic BACE inhibitors: Optimization of a micromolar hit to nanomolar leads
[Huang, Yifang; Strobel, Eric D.; Ho, Chih Y.; Reynolds, Charles H.; Conway, Kelly A.; Piesvaux, Jennifer A.; Brenneman, Douglas E.; Yohrling, George J.; Moore Arnold; Rosenthal, Daniel; Alexander, Richard S.; Tounge, Brett A.; Mercken, Marc; Vandermeeren, Marc; Parker, Michael H.; Reitz, Allen B.; Baxter, Ellen W. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 10 p. 3158 - 3160]
Synthesis of new antimicrobial pyrrolo [2, 1-a] isoquinolin-3-ones
[Moreno, Laura; Parraga, Javier; Galan, Abraham; Cortes, Diego; Cabedo, Nuria; Primo, Jaime Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 22 p. 6589 - 6597,9]
Synthesis of new antimicrobial pyrrolo [2, 1-a] isoquinolin-3-ones
[Moreno, Laura; Parraga, Javier; Galan, Abraham; Cortes, Diego; Cabedo, Nuria; Primo, Jaime Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 22 p. 6589 - 6597,9]