Identification and characterization of a periplasmic aminoacyl-phosphatidylglycerol hydrolase responsible for Pseudomonas aeruginosa lipid homeostasis

…, MK Groenewold, S Hebecker, JS Dickschat…

Index: Arendt, Wiebke; Groenewold, Maike K.; Hebecker, Stefanie; Dickschat, Jeroen S.; Moser, Juergen Journal of Biological Chemistry, 2013 , vol. 288, # 34 p. 24717 - 24730

Full Text: HTML

Citation Number: 11

Abstract

Background: Continuous adaptation of the bacterial membrane is required in response to changing environmental conditions. Results: Pseudomonas aeruginosa ORF PA0919 codes for an alanyl-phosphatidylglycerol hydrolase that is anchored to the periplasmic surface of the inner membrane. Conclusion: The elucidated enzymatic activity implies a new regulatory circuit for the fine tuning of cellular alanyl-phosphatidylglycerol concentrations.