Synthesis of unnatural amino acid derivatives via palladium-catalyzed 1, 4-addition of boronic acids
D Ray, AM Nyong, A Natarajan
Index: Ray, Devalina; Nyong, Abijah M.; Natarajan, Amarnath Tetrahedron Letters, 2010 , vol. 51, # 19 p. 2655 - 2656
Full Text: HTML
Citation Number: 2
Abstract
Our laboratory is interested in developing small molecule inhibitors of protein-protein interactions. Recent studies showed that the tetrapeptide pSPTF binds the carboxy terminus domains of the early onset breast cancer gene 1 (BRCT-BRCA1) with micromolar affinities. 1 Structural studies show that the phenylalanine residue (F) in pSPTF makes a key hydrophobic contact with the BRCT-BRCA1. 2 To explore this hydrophobic pocket we planned to ...
Related Articles:
The Heck–Matsuda arylation of 2-hetero-substituted acrylates
[De Azambuja, Francisco; Correia, Carlos Roque Duarte Tetrahedron Letters, 2011 , vol. 52, # 1 p. 42 - 45]
[Wang, Chun-Jiang; Gao, Feng; Liang, Gang Organic Letters, 2008 , vol. 10, # 21 p. 4711 - 4714]