Journal of medicinal chemistry

Carbamate derivatives related to meprobamate

BJ Ludwig, LS Powell, FM Berger

Index: Ludwig,B.J. et al. Journal of Medicinal Chemistry, 1969 , vol. 12, # 3 p. 462 - 472

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Citation Number: 30

Abstract

A series of 2-substituted 1, 3-propanediol dicarbamates, related chemically to meprobamate, has been prepared for central riervoiis system pharmacological investigation. The Y- uiisubstitiited propaiiediol dicarbamates were obtained by an ester-exchange reaction bet~ ween the corresponding diol niid nrethan, by phosgenation of the diol followed by amnioiiiatiori of the bis (ch1orocarboriate) derivative, by the reaction of the diol with cyanic ...