Selective antiproliferative activity of caffeic acid phenethyl ester analogues on highly liver-metastatic murine colon 26-L5 carcinoma cell line

T Nagaoka, AH Banskota, Y Tezuka, I Saiki…

Index: Nagaoka, Takema; Banskota, Arjun H; Tezuka, Yasuhiro; Saiki, Ikuo; Kadota, Shigetoshi Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 10 p. 3351 - 3359

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Citation Number: 134

Abstract

Caffeic acid phenethyl ester (CAPE, 2) and its twenty analogues (1, 3–21) were prepared. These esters were tested by MTT assay on growth of murine colon 26-L5 carcinoma, murine B16-BL6 malonoma, murine Lewis lung carcinoma, human HT-1080 fibrosarcoma, human lung A549 adenocarcinoma, and human cervix HeLa adenocarcinoma cell lines. It was found that CAPE analogues possessed selective antiproliferative activity toward highly ...