Iodine-and Indium (III) Chloride–Catalyzed Facile Syntheses of 1, 5-and 1, 8-Naphthyridines

KC Chunavala, S Adimurthy

Index: Chunavala, Kaushik C.; Adimurthy, Subbarayappa Synthetic Communications, 2011 , vol. 41, # 12 p. 1843 - 1851

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Abstract

1,5-Naphthyridines, nitrogen-containing heterocycles, are interesting molecules because they feature several favorable characteristics for drug development. [ 1 1. (a) Bemis , GW ; Murcko , MA The properties of known drugs. 1. Molecular frameworks . J. Med. Chem. 1996 , 39 , 2887 – 2893 ; (b) Waterbeemd , H. ; Smith , DA ; Beaumont , K. ; Walker , DK Property-based design: Optimization of drug absorption and pharmacokinetics . J. Med. Chem. 2001 , 44 , ...