Synthesis

Friedel-Crafts α-Aminoacylation of Aromatic Compounds with a Chiral N-Carboxy-α-amino Acid Anhydride (NCA); Part 2

O Itoh, A Amano

Index: Itoh, Osamu; Amano, Akira Synthesis, 1999 , # 3 p. 423 - 428

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Citation Number: 4

Abstract

Abstract: The N-carboxy-α-amino acid anhydrides (NCA) derived from L-Asp (OEt), L-Glu (OMe), L-Met, and L-Pro reacted with aromatic compounds (toluene or benzene) in the presence of AlCl3 to afford the corresponding α-aminoalkyl aryl ketones as hydrochloride salts in moderate yields. The β-and γ-amino acid esters, which were obtained from the reaction of the aromatic compounds with L-Asp (OEt)-and L-Glu (OMe)-NCA, were ...