An update on the chemistry and medicinal chemistry of novel antimycobacterial compounds

F Silva Castelo Branco, AC Pinto…

Index: Polaroid Corporation Patent: US4652635 A1, 1987 ;

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Citation Number: 6

Abstract

... Bedaquiline was synthesized for the original patent through a low-complexity route with 4 steps ... and circular dichroism, the stereogenic centers were determined for the enantiomer A1 (1R, 2S ... as OPC-67683) was devel- oped by the Japanese laboratory Otsuka, patented in 2004 ...