Tetrahedron letters

Synthesis of substituted 2-phenylhistamines via a microwave promoted Suzuki coupling

AP Skoumbourdis, S Moore, M Landsman…

Index: Skoumbourdis, Amanda P.; Moore, Susanna; Landsman, Marc; Thomas, Craig J. Tetrahedron Letters, 2007 , vol. 48, # 52 p. 9140 - 9143

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Citation Number: 11

Abstract

Substitutions on the 2-position of the imidazole ring of histamine have proven useful in a number of biochemical settings. Current art for the synthesis of these constructs relies upon a cumbersome and low-yielding condensation reaction. Here-in we report a new procedure for the synthesis of a series of substituted 2-phenylhistamines utilizing a microwave- promoted Suzuki coupling.