Carbovir-Related Compounds and Phosphonate Analogues

PT Pham, R Vince

Index: Pham, Phuong-T.; Vince, Robert Phosphorus, Sulfur and Silicon and the Related Elements, 2007 , vol. 182, # 4 p. 779 - 791

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Citation Number: 10

Abstract

Detailed syntheses of carbovir-related cis-[2-(9H-Purin-9-yl)-3-cyclopentene]-1-methanols and phosphonates of selected analogues are presented. Our interest in this chemistry stems from antiviral activity shown by closely related compounds. Access to the key β-lactam was achieved by the reaction of monocyclopentadiene with chlorosulfonyl isocyanate at− 78° C rather than at the reported 1 ambient temperature, where only the less ring-strained and ...

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