Steroids

Synthesis of 9α-hydroxysteroids by a Rhodococcus sp.

VK Datcheva, NE Voishvillo, AV Kamernitskii…

Index: Datcheva, Violeta K.; Voishvillo, Natalia E.; Kamernitskii, Aleksei V.; Vlahov, Radoslav J.; Reshetova, Irina G. Steroids, 1989 , vol. 54, # 3 p. 271 - 286

Full Text: HTML

Citation Number: 18

Abstract

Abstract 9α-Hydroxylation of Δ 5-3β-hydroxysteroids (of androstane, pregnane, 24-nor-and 21, 24-bisnorcholane groups) was carried out by a Rhodococcus sp., isolated from a petroleum-containing soil sample. A large number of the investigated steroids was transformed into 9α-hydroxy-Δ 4-3-ketones in satisfactory yields (50–90%) at high initial concentrations of the substrates (0.5–5.0 g/L). The influence of some structural features of ...