Kinetic analysis of fluorescein and dihydrofluorescein effluxes in tumour cells expressing the multidrug resistance protein, MRP1

…, C Loetchutinat, A Garnier-Suillerot

Index: Saengkhae, Chantarawan; Loetchutinat, Chatchanok; Garnier-Suillerot, Arlette Biochemical Pharmacology, 2003 , vol. 65, # 6 p. 969 - 977

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Citation Number: 22

Abstract

Multidrug resistance (MDR) in tumour cells is often caused by the overexpression of two transporters the P-glycoprotein (P-gp) and the multidrug resistance-associated protein (MRP1) which actively pump out multiple chemically unrelated substrates across the plasma membrane. A clear distinction in the mechanism of translocation of substrates by MRP1 or P- gp is indicated by the finding that, in most of cases, the MRP1-mediated transport of ...