Palladium-catalysed tandem alkenyl-and aryl-C–N bond formation: a cascade N-annulation route to 1-functionalised 7-azaindoles

RC Hodgkinson, J Schulz, MC Willis

Index: Hodgkinson, Roy C.; Schulz, Jurgen; Willis, Michael C. Tetrahedron, 2009 , vol. 65, # 44 p. 8940 - 8949

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Citation Number: 18

Abstract

A series of 3-(2-haloalkenyl)-2-pyridyl-halides undergo consecutive palladium-catalysed inter-and intramolecular amination reactions to deliver a series of 1-functionalised 7- azaindoles. Anilines and amines can be readily employed as the N-nucleophile and incorporation of both electron-donating and electron withdrawing substituents on the pyridine core is possible.