5-Hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity

PD Pierson, A Fettes, C Freichel…

Index: Journal of Medicinal Chemistry, , vol. 52, # 13 p. 3855 - 3868

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Citation Number: 22

Abstract

... Journal of Medicinal Chemistry. ... between the patient's expectation and the achievable weight loss under medication (typically 5% within 1 year) are hampering compliance.(7) Although a change of lifestyle remains an excellent therapy, there exists a large medical need for ...

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