Strong base-induced intramolecular cycloaddition of homophthalic anhydrides: an efficient synthesis of polycyclic peri-hydroxy aromatic compounds

Y Kita, R Okunaka, T Honda, M Shindo…

Index: Kita, Yasuyuki; Okunaka, Ryuichi; Honda, Takao; Shindo, Miki; Taniguchi, Miyako; et al. Journal of Organic Chemistry, 1991 , vol. 56, # 1 p. 119 - 125

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Citation Number: 26

Abstract

Considerable effort has been devoted to the synthesis of biologically important linear polycyclic peri-hydroxy aromatic compounds,'which include anthracyclines, 2 nogalamycin, 3 olivomycin, 4 bostrycin: granaticin: and other polycyclic antibiotics. In an effort to develop a new, efficient synthetic method for the preparation of these compounds, we have reported the strong-base-induced cycloaddition of homophthalic anhydrides (1) and their ...

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