Addition and substitution reactions of chloropyrimidines with lithium reagents

…, MJ Mokrosz, L Strekowski

Index: Harden, Donald B.; Mokrosz, Maria J.; Strekowski, Lucjan Journal of Organic Chemistry, 1988 , vol. 53, # 17 p. 4137 - 4140

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Citation Number: 47

Abstract

(3) The substitution of hydrogen in electron-deficient azaaromatics by the action of nucleophilic agents can formally be regarded as a hydride ion replacement. In the vast majority of cases these reactions proceed via a two-stage mechanism involving addition and elimination promoted by an oxidizing agent. For a recent review, see: Chupakin, 0. N.; Charushin, VN; van der Plas, HC Tetrahedron 1988, 44, 1.(4)(a) Elmoghayar, MRH; Groth, ...