Synthesis, biological active molecular design, and molecular docking study of novel deazaflavin–cholestane hybrid compounds

…, T Shindo, N Ashida, T Nagamatsu

Index: Shrestha, Ajaya R.; Shindo, Takashi; Ashida, Noriyuki; Nagamatsu, Tomohisa Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 18 p. 8685 - 8696

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Citation Number: 12

Abstract

Novel deazaflavin–cholestane hybrid compounds, 3′, 8′-disubstituted-5′-deazacholest- 2, 4-dieno [2, 3-g] pteridine-2′, 4′(3′ H, 8′ H)-diones, have been synthesized by condensation reaction between 6-(monosubstituted amino)-pyrimidin-2, 4 (1H, 3H)-diones and 2-hydroxymethylenecholest-4-en-3-one in presence of p-toluenesulfonic acid monohydrate and diphenyl ether. The antitumor activities against human tumor cell lines ( ...