Orally bioavailable 6-chloro-7-methoxy-4 (1 H)-quinolones efficacious against multiple stages of plasmodium

…, JN Burrows, DE Kyle, R Manetsch

Index: Cross, R. Matthew; Namelikonda, Niranjan K.; Mutka, Tina S.; Luong, Lisa; Kyle, Dennis E.; Manetsch, Roman Journal of Medicinal Chemistry, 2011 , vol. 54, # 24 p. 8321 - 8327

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Citation Number: 14

Abstract

The continued proliferation of malaria throughout temperate and tropical regions of the world has promoted a push for more efficacious treatments to combat the disease. Unfortunately, more recent remedies such as artemisinin combination therapies have been rendered less effective due to developing parasite resistance, and new drugs are required that target the parasite in the liver to support the disease elimination efforts. Research was initiated to ...