Expeditious Synthesis of Ramipril: An Angiotensin Converting Enzyme (ACE) Inhibitor

…, BV Bhaskar, PP Reddy, A Bhattacharya…

Index: Malakondaiah, Golla China; Gurav; Reddy, Lekkala Amarnath; Babu, Karrothu Srihari; Bhaskar, Bolugoddu Vijaya; Reddy, Padi Pratap; Bhattacharya, Apurba; Anand, Ramasamy Vijaya Synthetic Communications, 2008 , vol. 38, # 11 p. 1737 - 1744

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Abstract

Abstract We document an efficient and cost??effective synthesis of ramipril 1 utilizing (i) an environmentally benign process for the esterification of racemic 2??aza??bicyclo??[3.3. 0]?? octane??3??carboxylic acid hydrochloride 2 using boric acid as a catalyst and (ii) a robust resolution process for the synthesis of 3a by means of inexpensive and recyclable L??(+)?? mandelic acid as key steps.

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