Isoenzyme-specific glutathione-S-transferase inhibitors: design and synthesis

…, A Engqvist-Goldstein, JE Flatgaard…

Index: Lyttle; Hocker; Hui; Caldwell; Aaron; Engqvist- Goldstein; Flatgaard; Bauer Journal of Medicinal Chemistry, 1994 , vol. 37, # 1 p. 189 - 194

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Citation Number: 99

Abstract

Glutathione-S-transferase (GST) isozyme-selective inhibitors were designed by an empirically guided strategy. In the first phase, literature data were used to select C-terminal modifications which generated maximum variation in the catalytic efficiency (VdK?) for ...