Partition coefficient determination of a series of isoindolines-2-substituted and its correlation with their antiproliferative activity on HeLa cells

…, TM Percino, EM Jiménez, J Correa-Basurto…

Index: Munoz, Cynthia R. Trejo; Percino, Teresa Mancilla; Jimenez, Elvia Mera; Correa-Basurto, Jose; Ferrara, Jose G. Trujillo Medicinal Chemistry Research, 2013 , vol. 22, # 8 p. 4039 - 4045

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Abstract

Abstract In this study, the partition coefficients (Log P) of two series of isoindolines-2- substituted were calculated from the equation obtained for the multilinear correlation between the electronic properties: the highest occupied molecular orbital and the lowest unoccupied molecular orbital energies, and the steric property volume, and the experimental Log P values were determined for some representative isoindolines. Log P values ...