Canadian Journal of Chemistry

N-Methylamino acids in peptide synthesis. II. A new synthesis of N-benzyloxycarbonyl, N-methylamino acids

JR McDermott, NL Benoiton

Index: McDermott,J.R.; Benoiton,N.L. Canadian Journal of Chemistry, 1973 , vol. 51, p. 1915 - 1919

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Citation Number: 164

Abstract

Reaction of N-benzyloxycarbonyl derivatives of aliphatic amino acids, and threonine, aspartic, and glutamic acids whose side-chains were protected with the t-butyl group, gave the corresponding N-methylamino acid derivatives in good yields. The methionine derivative could be obtained by using only one mol of methyl iodide. Derivatives of threonine, and aspartic and glutamic acids whose side-chains were not protected could not be ...