Monosaccharide-responsive release of insulin from polymersomes of polyboroxole block copolymers at neutral pH

H Kim, YJ Kang, S Kang, KT Kim

Index: Kim, Hyunkyu; Kang, Young Ji; Kang, Sebyung; Kim, Kyoung Taek Journal of the American Chemical Society, 2012 , vol. 134, # 9 p. 4030 - 4033

Full Text: HTML

Citation Number: 118

Abstract

We synthesized a boroxole-containing styrenic monomer that can be polymerized by the reversible addition–fragmentation and chain transfer (RAFT) method. Poly (styreneboroxole)(PBOx) and its block copolymers with a poly (ethylene glycol)(PEG) as a hydrophilic block displayed binding to monosaccharides in phosphate buffer at neutral pH, as quantified by Wang's competitive binding experiments. By virtue of a controlled radical ...