Selective and Potent Monoamine Oxidase Type B Inhibitors: 2-Substituted 5-Aryltetrazoles Derivatives

…, S Gueddari, F Mazouz, S Bernard…

Index: Lebreton, Luc; Curet, Olivier; Gueddari, Salach; Mazouz, Fathi; Bernard, Suzanne; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4786 - 4792

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Citation Number: 26

Abstract

Twenty new 2-(cyanoalkyl) tetrazoles (15 and 16) and twenty new 2-(hydroxyalkyl) tetrazoles (17 and 18) were synthesized and investigated in vitro for their abilities to inhibit selectively rat brain monoamine oxidase (MAO) B over MA0 A. Most of them were MA0 B inhibitors and those bearing a substituted 44arylmethoxy) phenyl group in the position 5 of the tetrazole ring had IC50 values between 8 pM for 18d and 2 nM for 16a (30 nM for ...